🧠 ADHD PROFILE
Testosterone modulates dopaminergic signaling in the prefrontal cortex — the brain region most impaired in ADHD. Men with low testosterone have higher rates of attention and executive function complaints. The overlap between ADHD and low T isn't coincidence; it's shared neurobiology.
Helian's ADHD protocol times compounds for the AM peak window — when testosterone and cognitive performance are highest — and uses the PM to support the overnight neurological reset that determines the next day's focus capacity.
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“Testosterone facilitates prefrontal dopaminergic neurotransmission. Men with late-onset hypogonadism report significantly higher rates of cognitive complaints — inattention, working memory deficits, and executive dysfunction — than age-matched controls with normal testosterone.”
Janowsky et al., Psychopharmacology (1994), foundational testosterone-cognition study
Testosterone primes dopamine
Testosterone upregulates D1 and D2 dopamine receptors in the prefrontal cortex and slows dopamine reuptake — creating more sustained dopaminergic activity. When testosterone falls, dopamine signaling degrades, making focus harder and impulsivity control weaker.
AM window = peak focus
Testosterone peaks 20–25% higher in the AM than the evening. Cognitive performance peaks here too. The ADHD protocol front-loads dopamine-supporting compounds in the AM to align with this neurobiological window — compounds that reduce reuptake and support receptor sensitivity.
Sleep debt destroys attention first
Sleep deprivation disproportionately impairs prefrontal cortex function — the same circuits already compromised in ADHD. The PM stack targets sleep architecture quality: deep sleep is when dopaminergic reset occurs.
ADHD STACK
The most evidence-backed supplement for attention and working memory. Multiple RCTs show significant improvement in ADHD-adjacent cognitive function. Supports dopaminergic receptor sensitivity and reduces cortisol-driven cognitive impairment. Take in the AM peak window.
Stimulates nerve growth factor (NGF) production — neuroplasticity in the prefrontal cortex. Takes 4–8 weeks to accumulate neurotropic effects. Daily consistency matters more than dose timing, but AM is preferred for alertness.
DHA is a structural component of prefrontal cortex cell membranes. Multiple meta-analyses confirm omega-3 reduction in ADHD symptom severity, particularly inattention. A structural foundation, not a stimulant.
Zinc regulates dopamine transporter activity and is a cofactor in dopamine synthesis. Zinc deficiency is significantly more common in ADHD populations. Bisglycinate form avoids the nausea of zinc sulfate and maximizes absorption.
Modulates dopamine and serotonin without stimulant mechanisms. Improves mental fatigue and reaction time in human trials. No habituation, no PM crash, no cortisol spike. AM timing leverages the cortisol awakening response.
The amino acid precursor to dopamine (and norepinephrine). Supports dopamine synthesis during cognitively demanding tasks and stress. Most effective when taken 30–60 minutes before high-complexity work. Does not cause dependency.
Magnesium deficiency is more prevalent in ADHD than in the general population — chronic sympathetic activation depletes it. PM timing supports the sleep architecture that determines next-day cognitive function.
Reduces the elevated cortisol that suppresses dopaminergic function. Men with ADHD often have elevated baseline cortisol, which impairs prefrontal dopamine availability. PM timing allows overnight HPA axis normalization.
“I've been managing ADHD for 15 years. The AM stack is the first thing that actually makes my medication work better, not replace it.”
Dan T., 38
ADHD PROFILE
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$39/mo Essential or $69/mo Full Protocol — price locked forever.