Helian · Research Dispatch
Real research from the past six months — curated for men who want to understand the circadian, ultradian, and seasonal rhythms driving testosterone, cortisol, sleep, and metabolism. Every finding in plain language and mechanistic depth.
Parallel to the estrobolome, a 2025 NPJ Biofilms and Microbiomes paper formally defines the testobolome — gut bacteria that degrade and transform testosterone in men, with direct implications for hormone levels and male reproductive health.
A September 2025 Asian Journal of Andrology review establishes that the circadian clock proteins BMAL1 and CLOCK directly regulate testosterone synthesis in Leydig cells — and that disrupting sleep disrupts steroidogenesis at the molecular level.
Source: Asian Journal of Andrology
A Journal of Urology 2025-2026 paper proposes integrating circadian thresholds and organ-specific testosterone effects into testosterone deficiency diagnosis — moving beyond the single morning total-T measurement that misses 30-40% of functional hypogonadism cases.
Source: Journal of Urology / AUA
A 2025 meta-analysis confirms statistically significant cortisol reduction (−1.16 µg/dL) from ashwagandha, but finds no effect on perceived stress scores. The distinction matters: biological cortisol suppression and subjective stress perception are separate systems.
Source: PubMed (PMID 40746175)
A 2025 circadian medicine study found that men with nocturia (nighttime urination) have chronically suppressed testosterone — and that relieving nocturia raises testosterone even in men with "normal" baseline levels, revealing sleep disruption as an underdiagnosed T-suppression mechanism.
Multiple 2025 studies confirm that GLP-1 receptor agonists (semaglutide, tirzepatide) substantially increase testosterone in men with obesity-related hypogonadism — not just through weight loss, but through direct effects on Leydig cells and the HPG axis. For men with low-normal T and metabolic issues, this changes the conversation.
Source: Journal of Urology / Journal of Clinical Endocrinology & Metabolism / Andrology
Growth hormone secretagogues, BPC-157, TB-500, PT-141, and more — the peptide space has exploded in men's health and fitness communities. Here's a structured breakdown of what the actual 2025 research supports, stratified by evidence quality and relevant to men's hormonal and metabolic health.
Source: Journal of Endocrinology / Peptides / FDA / NIH ClinicalTrials
Helian Research Dispatch is updated as significant findings emerge. All studies linked to their primary source. Helian supplements are not diagnostic tools — always work with your clinician for treatment decisions.